Selected publications

2025

Padmanabhan A, Rahman D, Zhu R, Khorbtli S, Sathianathan S, Le Flohic B, Assanga Bisse L, Mollereau B, Huang C, Konstantinides N, Issa AR. Lifelong maintenance of locomotion by embryonically active dopamine neurons. bioRxiv (2025).

Celle M, Aniorte S, Issa AR, Falabregue M, Jin H, Sanchez-Mirasierra I, Ding S, Soukup SF, Seugnet L, Liao L, Lesca G, Walter L, Mollereau B. A dwdr45 knock-out drosophila model to decipher the role of autophagy in BPAN. Hum Mol Genet. (2025).

2023

Mollereau B, Hayflick, Issa AR, et al. A burning question from the first international BPAN symposium: is restoration of autophagy a promising therapeutic strategy for BPAN? Autophagy (2023);19(12):3234-3239.

2022

Issa AR*, Menzies JAC , Padmanabhan A and Alonso C.R*. A novel post-developmental role of the Hox genes underlies normal adult behaviour. PNAS (2022) ;119(49):e2209531119. (*) co-corresponding.

2021

Dulac A., Issa AR, Sun J., Matassi G., Chérif-Zahar B., Cattaert D., Birman S. A novel and specific regulator of neuronal V-ATPase in Drosophila. eNeuro (2021). ENEURO.0193-21.

Klann M., Issa AR, and Alonso C.R. microRNA-dependent control of sensory neuron function regulates posture behaviour in Drosophila. J. Neurosci (2021) ; 10.1523/JNEUROSCI.0081-21.2021.

2019

Issa AR.*, Picao-Osorio J.*, Rito N., Chiappe M.E. and Alonso C.R. A Single microRNA-Hox gene module controls equivalent movements in biomechanically distinct forms of Drosophila. Curr. Biol. (2019) ; 29(16),2665-2675.e4.(*) Equal contribution.

Robin M., Issa AR, Birman S. and Mollereau B. Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress. Autophagy (2019) ; 15(5):771-784.

2018

Issa AR, Sun J., Petitgas C., Mesquita A., Dulac A., Jenny A., Chérif-Zahar B., and Birman S. The lysosomal membrane protein LAMP-2A promotes autophagosome formation and prevents Parkinson’s disease-like symptoms in the Drosophila brain. Autophagy (2018) ;14(11):1898-1910.

2017

Vaccaro A., Issa AR, Seugnet L., Birman S. and Klarsfeld A. Locomotor Aging in a Drosophila Clock Mutant Links Circadian and Dopaminergic Neuron Subsets in the Central Brain. Plos Genetics (2017). 13(1):e1006507.

2015

Cassar* M., Issa AR*, Riemensperger T.*, Petitgas C., Rival T., Coulom H., Iché-Torres M., Han K.-A. and Birman S. A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum Mol Genet.(2015) Jan 1 ; 24(1):197-212.

2013

Riemensperger T, Issa AR*, Pech U.*,Coulom H, Nguyễn M-V, Cassar M., Jacquet M., Fiala A. and Birman S. A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. Cell Reports (2013),5:1-9. (*) Equal contribution.